Haemodynamic effects of isopropylnoradrenaline sulphate (isoprenaline) following aortic valve homograft replacement.

Isopropylnoradrenaline sulphate (isoprenaline) is a sympathomimetic drug having an action predominantly on the ,B-receptors of the sympathetic system (Moran, 1963). It has been shown in normal man to have positive inotropic and chronotropic actions on the myocardium, producing increases in heart rate, stroke volume, and cardiac output (Weissler, Leonard, and Warren, 1959). The drug is used extensively following heart operations, and this investigation is an attempt to clarify its action following aortic valve replacement.